WebMar 22, 2024 · Bisphenol S (BPS) is associated with neurotoxicity, but its molecular mechanisms are unclear. Our aim was to investigate the role of the brain-derived … WebMar 21, 2024 · Heterozygous mice with reduced expression of TrkB specifically in PV + interneurons (PV-TrkB hCKO; PV cre/wt, TrkB flx/wt ), and littermate control mice that …
Activation of the TrkB-ERK-CREB signaling pathway as a
WebApr 7, 2024 · The brain-derived neurotrophic factor/tropomyosin receptor kinase B/cAMP response element-binding protein (BDNF/TrkB/CREB) signaling pathway is a critical therapeutic target for inducing adult hippocampal neurogenesis and antidepressant therapy. In this study, we tested the hypothesis that naringin, a natural medicinal compound, could … WebActivation of BDNF/TrkB signaling protects against TBI through cAMP-response element binding protein (CREB) cascade (Wu et al., 2014). CREB is a transcription factor in the … honey bee new york times
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WebFeb 24, 2024 · Brain-derived neurotrophic factor (BDNF) and its receptors tropomyosin kinase receptor B (TrkB) and the p75 neurotrophin receptor (p75) are the primary regulators of dendritic growth in the CNS. After … WebOct 20, 2024 · BDNF elicits its physiological function by binding with the specific cell surface tropomyosin-related kinase receptor B (TrkB) receptor. Subsequently, the activation of BDNF/TrkB signaling leads to the phosphorylation and activation of the protein kinase B (Akt) and transcription factor cAMP response element-binding protein (CREB) [13,14]. WebJul 30, 2024 · PHF2 promotes the expression of memory-related genes by epigenetically reinforcing the TrkB–CREB signaling pathway. In behavioral tests, memory formation is enhanced by transgenic overexpression of PHF2 in mice, but is impaired by silencing PHF2 in the hippocampus. honey bee new jersey