WebSep 1, 2024 · Deiodinase type II enzyme play a central role in the conversion of thyroxin to the active form triiodothyronine. This study searches the effect of rs225014; 274 T>C single nucleotide polymorphism (SNP) of deiodinase type II (DIO2) gene on the clinical response to levothyroxine replacement therapy in Iraqi hypothyroidism patients. WebGene ID: 1733, updated on 25-Sep-2024. Summary. The protein encoded by this gene belongs to the iodothyronine deiodinase family. It catalyzes the activation, as well as …

Pathophysiological relevance of deiodinase polymorphism

WebFeb 6, 2016 · To date, there are several non fatal single nucleotide gene polymorphisms (SNP’s) which have been found in DIO genes, and some of them are found to be altered phenotypic expression [21] . Single amino acid changes in the active centre of DIO2 raises K m or lowers V max and substrate induced loss of DIO2 by ubiquitination [18] [22] . WebSep 20, 2024 · this information, we can conclude that the effects of gene polymorphisms associated with BAT may be gr eater in childhood obesity than in adulthood. T ype 2 deiodinase (DIO2) converts thyroxine to ... funny donald duck gif

Prevalent Polymorphism in Thyroid Hormone-Activating Enzyme …

WebApr 21, 2024 · Metabolites 2024, 12, ... A common polymorphism in the gene encoding the activating deiodinase (Thr92Ala-D2) is known to be associated with quality of life in millions of patients with ... WebAug 26, 2024 · Background Thyroid hormone (TH) metabolism can have prognostic significance in brain tumors. We studied the association of common variations in three … WebFeb 18, 2024 · Object: To explore the relationship between type 2 deiodinase gene polymorphism and the TSH inhibitory treatment efficacy in thyroid cancer patients with … gis jobs in ethiopia 2023