Ctf4 elife
WebJul 16, 2024 · DOI: 10.7554/eLife.47405 Primary Citation of Related Structures: 6PTJ, 6PTN, 6PTO PubMed Abstract: The current view is that eukaryotic replisomes are … WebJun 4, 2024 · Multiple factors associate directly with CMG, including Ctf4 and the heterotrimeric fork protection complex (Csm3/Tof1 and Mrc1), which has important roles including aiding normal replication rates and stabilizing stalled forks. How these proteins interface with CMG to execute these functions is poorly understood.
Ctf4 elife
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WebCTF4 1 Systematic Name YPR135W SGD ID SGD:S000006339 Aliases CHL15 5 , POB1 5 Feature Type ORF , Verified Description Chromatin-associated protein; required for … WebJun 24, 2009 · Ctf4 is a constituent of the replication machinery ( Gambus et al. 2006; Lengronne et al. 2006) and the corresponding deletion mutation causes synthetic growth …
WebChromosome transmission fidelity 4 (Ctf4) is a conserved protein required for DNA replication. In this report, interactions between human Ctf4 (hCtf4) and the replicative … WebThe Mcm2-Ctf4-Polα Axis Facilitates Parental Histone H3-H4 Transfer to Lagging Strands Gan H, Serra-Cardona A, Hua X, Zhou H, Labib K, Yu C, Zhang Z Mol Cell. 2024. PMID: 30244834, DOI: 10.1016/j.molcel.2024.09.001 A mechanism for preventing asymmetric histone segregation onto replicating DNA strands
http://www.4m4life.com/ WebMar 2, 2024 · Ctf4 organizes sister replisomes and Pol alpha into a replication factory. Elife. 2024; 8 e47405. Google Scholar), which could allow some degree of coordination of their movement ... Elife. 2024; 8 e47405. Google Scholar). However, in vitro evidence indicates that replisomes can function as monomers (Yardimci et al., 2010. Yardimci H. Loveland …
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WebOct 30, 2013 · Chromosome transmission fidelity 4 (Ctf4) is a conserved protein required for DNA replication. In this report, interactions between human Ctf4 (hCtf4) and the … shaper son snowboardWebCtf4 is a protein conserved in eukaryotes and a constituent of the replisome progression complex. It also plays a role in the establishment of sister chromatid cohesion. In our … shapers of westcliffWebJun 24, 2009 · CTF4 deletion leads to low level of replication checkpoint activation Ctf4 is a constituent of the replication machinery (Gambus et al. 2006; Lengronne et al. 2006) and the corresponding deletion mutation causes synthetic growth defects when combined with a loss of the DNA replication checkpoint genes, MRC1, TOF1 ... pony island ticket guideWebApr 20, 2024 · A recently solved crystal structure of Ctf4 showed that DUF3639 is part of a novel WD40-related domain that forms a β-propeller with six blades (β-6-prop), forming a stable trimer . The carboxyl-terminal end of Ctf4 extends as α-helical fold that can interact with a motif found in both DNA-Polα and Sld5 . Sld5 is part of the GINS complex ... pony island ticket endingshapers permanentWebAug 4, 2016 · Ctf4 forms a homotrimer that has the potential to connect the CMG helicase to one or two Pol α complexes, via the α-helical bundle at the carboxyl terminus of each Ctf4 protomer, which binds to a short conserved motif in the GINS component of CMG and the Pol1 catalytic subunit of Pol α (Simon et al., 2014 ). shapers pharmacy in northsideWebAug 4, 2016 · These observations formed the basis for a model of the eukaryotic replisome, in which the CMG helicase is connected directly to the leading strand polymerase ε and … shapers of worlds