WebOct 1, 2024 · Cell division cycle 25 (Cdc25) phosphatase is an attractive target for drug discovery. The rapid assembly and in situ screening of focused combinatorial fragment libraries using efficient modular reactions is a highly robust strategy for discovering bioactive molecules. In this study, we have utilized miniaturized synthesis to generate several … WebCrystals of 4a and 5a were obtained by crystallization from dichloromethane; crystals of 6 were obtained by crystallization from chloroform. Data were obtained on an Oxford Diffraction Gemini Adiffractometer with a CCD area detector, and the CrystAlisPro and CrysAlis RED software packages were used for data collection and data integration [20] .
Small Molecule X-ray Crystallography Facility at JHU
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Rigaku Oxford Diffraction forum
WebData collection and data processing are done using the latest CrystAlisPro software. Structure solution, refinement and report are done in either OLEX 2 or SHELX. … WebDec 1, 2024 · Introduction. The crystalline sponge method is a technology allowing precise, unambiguous molecular determination of a non-crystalline compound which would otherwise be not suitable for single crystal X-ray diffraction (SCXRD) analysis due to its state in isolation, such as powder, amorphous solid, liquid, volatile matter or oil. WebOct 3, 2024 · the CrystAlisPro software suite. The structure was solved and refined. using the ShelXS and ShelXL programs through the OLEX2. software. 42. The geometry was subjected to the appropriate ... bradford white water heater sizing guide